Fig. 5.

Colonic adenoma susceptibility is associated with changes in bile acid metabolism. a Dendrogram was generated based on the putative fecal metabolite features using the Euclidean distance of measurement and Wards clustering algorithm. The major root of the tree clustered samples independent of genetic lineage and GM profile. b Linear Discriminant Analysis (LDA) was used to identify the metabolites driving separation between the low-adenoma and high-adenoma clusters identified by the dendogram. c Scatter plots displaying relative abundance of two bile acids identified by tandem MS, significantly over-represented in the low-colonic adenoma group defined by the dendogram analysis (Min/J_GMJAX,n = 6; Min/D_GMJAX,n = 4; Min/J_GMHSD,n = 5; Min/D_GMHSD, n = 4). *p < 0.05, **p < 0.01; student’s t-test