TABLE 4.

Potential new directions for cancer research related to COVID‐19

	Focus	Potential benefit(s)
Basic science
Immune response to SARS‐CoV‐2	Define immune pathways Define immune therapeutic targets Define antibody induction and duration	Redirection of new knowledge toward understanding and implementing immunotherapies for pediatric cancer
ACE2 receptor	Explore role in lung metastases	Increased understanding for tumor immunology
Endothelial cell activation	COVID‐19‐related microangiopathy and thrombosis	Increased understanding for vascular metastasis and thrombosis
Clinical research
Biorepository	Collect samples prospectively, analyze retrospectively	Define mechanism of action and biologic effects as new diagnostics and therapies advance
Repurposing cancer therapeutics
Data collection on cancer patients with and without COVID‐19	Define influence of COVID‐19 on cancer outcomes
Epidemiology studies	SARS‐CoV‐2 and risk for childhood malignancies