TABLE 1.
Phase separation prediction of the SARS‐CoV‐2 N protein and known human LLPS proteins
| Protein | Pscore | catGRANULE |
|---|---|---|
| FUS (NM_004960) | 13.96 | 5.75 |
| hnRNPA1 (NM_031157) | 13.89 | 4.89 |
| EWSR1 (NM_013986) | 9.41 | 3.34 |
| hnRNPA2B1 (NM_031243) | 14.06 | 4.66 |
| hnRNPDL (NM_031372) | 16.83 | 2.09 |
| TAF15 (NM_139215) | 18.48 | 6.29 |
| TDP43 (NM_007375) | 5.95 | 2.04 |
| TIA1 (NM_022173) | 5.57 | 0.97 |
| N Protein (SARS‐CoV‐2) | 2.49 a | 1.65 b |
The Pscore and catGRANULE score for RNA‐binding proteins commonly linked to stress granules and LLPS were calculated using PSP 9 and catGRANULE, 8 respectively.
a
In the 86th percentile for all proteins in the human proteome (Uniprot proteome UP000005640).
b
catGRANULE currently does not support whole‐proteome analyses. However, another human protein, TRA2A, has a score of 2.14 and ranks 188th out of 20 190 human proteins, placing it in the 99th percentile. 11