Table 3.
Steroidogenic Enzyme Expression in Ovarian SCT-NOS.
| Enzyme | Gene | Case 1 |
Case 2 |
Case 2 |
Case 3 |
||||
|---|---|---|---|---|---|---|---|---|---|
| LT ovary SCT-NOS | H-score | LT ovary SCT-NOS | H-score | RT ovary SCT-NOS | H-score | RT ovary SCT-NOS | H-score | ||
| CYP11A1 | CYP11A1 | + | 199.492 | + (weak) | 22.886 | + | 168.293 | + | 175.099 |
| CYP17A1 | CYP17A1 | + | 173.367 | + | 147.419 | + | 184.529 | + | 180.549 |
| CYP19A1 | CYP19A1 | + | 180.944 | + | 187.654 | + (weak) | 96.132 | + | 287.459 |
| CYP21 | CYP21A2 | − | 0.495 | − | 1.938 | − | 0.648 | + (weak) | 77.336 |
| HSD3B2 | HSD3B2 | + | 161.673 | + | 114.65 | + (weak) | 89.88 | + | 114.175 |
| HSD17B1 | HSD17B1 | + | 181.624 | + | 165.089 | + | 103.299 | + | 190.157 |
| HSD17B2 | HSD17B2 | − | 2.111 | + | 192.386 | + | 194.015 | + (weak) | 64.426 |
| HSD17B3 | HSD17B3 | − | 9.091 | + (weak) | 83.242 | + (weak) | 74.829 | + | 173.114 |
| AKR1C3 | AKR1C3 | + | 155.309 | + | 171.306 | + | 177.76 | + | 168.952 |
| SRD5A1 | SRD5A1 | + (weak) | 20 | + (weak) | 18.039 | - | 0.231 | + | 187.359 |
| SRD5A2 | SRD5A2 | + | 197.821 | + | 185.714 | + | 195.641 | + | 131.992 |
| SULT2A1 | SULT2A1 | + | 148.196 | + | 153.15 | + (weak) | 95.77 | + | 183.893 |
| EST | SULT1E1 | + | 176.679 | + | 179.513 | + | 137.408 | + (weak) | 94.155 |
Abbreviations: SCT-NOS, steroid cell tumors, not otherwise specified; LT, left; RT, right; CYP11A1, cholesterol side-chain cleavage enzyme; CYP17A, 17α-hydroxylase; CYP19A1, aromatase; CYP21, 21α-hydroxylase; HSD3B2, 3β-hydroxysteroid dehydrogenase-2; HSD17B1, 17β-hydroxysteroid dehydrogenase-1; HSD17B2, 17β-hydroxysteroid dehydrogenase-2; HSD17B3, 17β-hydroxysteroid dehydrogenase-3; 17-βHSD5/AKR1C3, 17β-hydroxysteroid dehydrogenase-5/aldo-keto reductase 1C3; SRD5A1, 5α-reductase type 1; SRD5A2, 5α-reductase type 2; SULT2A1, steroid sulfatase; EST, estrogen sulfotransferase.