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. 2020 Jun 26;48(6):0300060520931242. doi: 10.1177/0300060520931242

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© The Author(s) 2020

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — Effect of interstitial cells in the tumor microenvironment on EMT in LOVO colon cancer cells. Expression levels of cell target proteins (E-cadherin and N-cadherin) were determined by western blot (a, b). Compared with the LOVO, *, P < 0.05; **, P < 0.01; compared with the LOVO+NFs, ^#, P < 0.05; ^##, P < 0.01. The induction of the FAK pathway, which is involved in EMT in colon cancer cells, by CAFs, was analyzed by western blot (c) and (d).

EMT, epithelial–mesenchymal transition; NFs, normal fibroblasts; FAK, focal adhesion kinase; CAFs, cancer-associated fibroblasts.