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Proposed mechanism of AZM inhibition of bacteria induced MMP9 secretion by human bronchial epithelial cells. AZM suppresses the phosphorylation of ERK1/2, which subsequently diminishes the activity of AP-1. Inactivation of AP-1 reduces transcription of the MMP9 gene.
AZM, azithromycin; MMP9, matrix metalloproteinase 9; ERK, extracellular signal-regulated kinase; AP-1, activator protein-1.
