Figure 5.

Simulated plasma and lung concentrations of azithromycin (AZ; 500 mg on day 1 followed by 250 mg daily for 4 days) relative to in vitro half‐maximal effective concentration (EC₅₀) values (a) and the effect of reduced lung pH (b) and renal impairment (c). Total plasma (red line), lung mass total (blue solid line), lung mass unbound (blue dashed line), epithelial lining fluid (ELF; yellow line) are shown. R_EC₉₀: Ratio of the simulated lung mass unbound concentration to effective concentration 90% (EC₉₀) value (8.65 µM) against severe acute respiratory syndrome‐coronavirus 2 virus in Vero E6 cells. GFR, glomerular filtration rate.