Table 4.
Pathological findings
| Case | Gross lung weights (g) † | Histological diagnosis(es) | Scoring of histological features*, mean (range) | Underlying chronic changes | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hyaline membranes | Fibrin thrombi | Airspace organisation | AFOP‐like fibrin | Acute bronchopneumonia | Perivascular inflammation/endothelialitis | Fibrinoid vessel wall necrosis | Haemorrhage and/or capillaritis | ||||
| SARS‐CoV‐2‐positive inpatient cohort | |||||||||||
| 1 | R: 1520; L: 1330 | DAD | 2 (2) | 1.7 (1–3) | 0 (0) | 1 (1) | 1.3 (1–2) | 0 (0) | 0 (0) | 0 (0) | – |
| 2 | R: 1300; L: 1100 | DAD | 1 (1) | 2 (2) | 0.7 (0–1) | 1.7 (1‐2) | 1 (0–2) | 0.3 (0–1) | 0 (0) | 0 (0) | – |
| 3 | R: 750; L: 700 | DAD ‡ | 3 (3) | 1 (0–2) | 1.3 (1–2) | 0.7 (0–1) | 1 (0–2) | 0 (0) | 0 (0) | 0 (0) | Diffuse alveolar septal amyloidosis |
| 4 | R: 840; L: 640 | DAD | 1.7 (1–2) | 0.3 (0–1) | 1 (0–2) | 1 (1) | 0 (0) | 0.7 (0–1) | 0 (0) | 0 (0) | – |
| SARS‐CoV‐2‐positive community cohort | |||||||||||
| 5 | R: 800; L: 700 | DAD | 3 (3) | 1 (1) | 0 (0) | 0.7 (0–1) | 0 (0) | 0.3 (0–1) | 0 (0) | 0 (0) | – |
| 6 | R: 750; L: 775 | DAD | 2 (2) | 0.7 (0–1) | 0 (0) | 1 (1) | 0.3 (0–1) | 1 (1) | 0 (0) | 0 (0) | – |
| 7 | R: 450; L: 450 | Focal fibrinous pneumonia ‡ | 0.3 (0–1) | 1 (1) | 0 (0) | 1 (1) | 0 (0) | 0.3 (0–1) | 0 (0) | 0 (0) | Metastatic calcifications |
| 8 | R: 1400; L: 1100 | DAD | 3 (3) | 0 (0) | 0 (0) | 0.3 (0–1) | 1 (1) | 0.3 (0–1) | 0 (0) | 0 (0) | – |
| Control inpatient cohort | |||||||||||
| 9 | R: 980; L: 840 | DAD | 2 (2) | 1.3 (1–2) | 0 (0) | 0.3 (0–1) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | – |
| 10 | R: 750; L: 750 | DAD | 2.3 (2–3) | 0.3 (0–1) | 1.3 (1–3) | 1.7 (1–2) | 0 (0) | 0.3 (0–1) | 0 (0) | 0 (0) | – |
| 11 | R: 970; L: 750 | DAD | 2 (2) | 1 (1) | 0 (0) | 2 (2) | 1.7 (1–3) | 0 (0) | 0 (0) | 0 (0) | Bronchiectasis |
| 12 | R: 860; L: 510 | DAD | 1.7 (1–2) | 0 (0) | 0 (0) | 2.7 (2–3) | 1 (0–2) | 0 (0) | 0 (0) | 0 (0) | Metastatic spindle cell neoplasm |
| Control community cohort | |||||||||||
| 13 | R: 620; L: 420 | DAD | 2.3 (2–3) | 0.3 (0–1) | 1 (0–3) | 0.7 (0–1) | 1 (1) | 0 (0) | 0 (0) | 0 (0) | – |
| 14 | R: 1150; L: 1280 | Acute necrotising BP and DAD | 1.7 (1–2) | 1.3 (1–2) | 0 (0) | 1.3 (1–2) | 3 (3) | 0 (0) | 0.7 (0–2) | 0 (0) | – |
| 15 | R: 1150; L: 920 | Acute BP and DAD ‡ | 1.3 (0–2) | 3 (3) | 0 (0) | 1.3 (1–2) | 3 (3) | 0 (0) | 0 (0) | 0 (0) | IV drug abuser’s lung |
| 16 | R: 1600; L: 1350 | DAD | 2 (2) | 0 (0) | 2.3 (2–3) | 2 (2) | 0.3 (0–1) | 0 (0) | 0 (0) | 0 (0) | – |
AFOP, acute fibrinous and organising pneumonia; BP, bronchopneumonia; DAD, diffuse alveolar damage; IV, intravenous; L, left; R, right; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2.
*
Scoring scale: 0 = absent; 1 = rare/focal; 2 = patchy; 3 = diffuse.
†
Normal average adult lung weights: R = 300–350 g; L = 250–300 g.
‡
Most common histological diagnosis listed, but no consensus diagnosis.