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A, Phylogenetic tree constructed from nucleotide sequence of the SH gene from 137 clinical specimens collected between March 2016 and March 2018 and from indicated reference sequences in GenBank. The dashed line indicates a cluster SH gene sequences encoding the N64D variant. B, Number of sequences encoding either the asparagine (N) or aspartic acid (D) variant at amino acid 64 of SH protein by month of collection among all patients (n = 137).
