Table 5.
Survival Analysis Results for Infants in High Child Mortality Settings During Follow-up to 1 Year of Age
| IgA Threshold, U/mL | n (%) (N = 2526) | Any Severity of Rotavirus Gastroenteritis (n = 2526) | Severe Rotavirus Gastroenteritis (n = 2409) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Events, n (%) | Time at Risk, wk | Cumulative Hazard per 100 (95% CI) | HRa (95% CI) | Events, n (%) | Time at Risk, wk | Cumulative Hazard per 100 (95% CI) | HRa (95% CI) | ||
| Seronegative | 978 (38.7) | 73 (2.9) | 27 166 | 9.98 (5.74–14.21) | 1.00 (ref) | 23 (1.0) | 26 012 | 2.70 (1.59–3.80) | 1.00 (ref) |
| ≥20 | 1548 (61.3) | 49 (1.9) | 44 976 | 3.41 (2.45–4.36) | 0.41 (.28–.59) | 18 (0.7) | 44 060 | 1.26 (.68–1.84) | 0.46 (.25–.86) |
| ≥40 | 1354 (53.6) | 43 (1.7) | 39 333 | 3.43 (2.40–4.46) | 0.41 (.28–.60) | 16 (0.7) | 38 557 | 1.29 (.66–1.92) | 0.47 (.25–.89) |
| ≥80 | 1058 (41.9) | 31 (1.2) | 30 804 | 3.14 (2.03–4.25) | 0.38 (.25–.68) | 9 (0.4) | 30 174 | 0.93 (.32–1.53) | 0.34 (.16–.73) |
| ≥160 | 795 (31.5) | 23 (0.9) | 23 114 | 3.13 (1.84–4.41) | 0.37 (.23–.60) | 5 (0.2) | 22 604 | 0.69 (.08–1.29) | 0.25 (.10–.66) |
| ≥320 | 546 (21.6) | 11 (0.4) | 15 903 | 2.14 (.87–3.41) | 0.26 (.14–.49) | 2 (0.1) | 15 544 | 0.39 (.00–.93) | 0.15 (.03–.62) |
| ≥640 | 336 (13.3) | 6 (0.2) | 9809 | 1.93 (.38–3.47) | 0.23 (.10–.53) | 1 (0.0) | 9555 | 0.32 (.00–.94) | 0.12 (.02–.88) |
| ≥1280 | 171 (6.8) | 2 (0.1) | 4944 | 1.23 (.00–2.93) | 0.15 (.04–0.62) | 1 (0.0) | 4835 | 0.63 (.00–1.86) | 0.25 (.03–1.74) |
| ≥2560 | 73 (2.9) | 0 (0.0) | 2088 | 0.00 (NA) | 0.00 (NA) | 0 (0.0) | 2059 | 0.00 (NA) | 0.00 (NA) |
Spearman correlation between IgA threshold and HR for any severity:, ρ = −0.99, P value < .000; severe, ρ = −0.87, P value = .005.
Abbreviations: CI, confidence interval; HR, hazard ratio; IgA, antirotavirus immunoglobulin A; NA, not applicable.
aModels include study as a frailty term.