Table 3.
Fully Adjusted Multivariable Model Assessing the Relationship of T-cell Subsets With Diabetes by HIV Status
| T-cell Subset | HIV Positive | HIV Negative | ||
|---|---|---|---|---|
| Odds Ratio (95% CI)a | P Value | Odds Ratio (95% CI)a | P Value | |
| CD4+ T-cell Subsets | ||||
| CD4+ naive | 0.99 (0.86–1.14) | .88 | NL | .003 |
| CD4+CD38+ | NL | .01 | 0.80 (0.64–1.00) | .05 |
| CD4+CD57+ (senescent) | NL | .007 | 0.83 (0.66–1.02) | .08 |
| CD4+CD45RO+ (memory) | 1.19 (1.03–1.38) | .02 | 1.19 (1.00–1.41) | .05 |
| CD4+ central memory | NL | .02 | 1.18 (1.00–1.39) | .05 |
| CD4+ transitional memory | 0.98 (0.85–1.13) | .79 | NL | .01 |
| CD4+ effector memory | 0.81 (0.69–0.95) | .01 | 1.00 (0.80–1.25) | .98 |
| CD4+ TEMRA | 0.87 (0.75–1.00) | .06 | 1.07 (0.83–1.37) | .62 |
| CD4+ TH1 | 1.03 (0.90–1.19) | .64 | 1.10 (0.91–1.32) | .34 |
| CD4+ TH2 | 1.05 (0.92–1.19) | .47 | 0.82 (0.63–1.07) | .14 |
| CD4+ TH17 | 0.97 (0.84–1.12) | .71 | 0.76 (0.52–1.10) | .14 |
| CD4+CD28− | 0.83 (0.71–0.97) | .02 | 1.06 (0.82–1.36) | .66 |
| CD4+CD25+FoxP3+ | 1.01 (0.86–1.18) | .89 | 1.04 (0.91–1.20) | .53 |
| CD8+ T-cell Subsets | ||||
| CD8+ naive | 1.18 (1.00–1.38) | .05 | NL | .02 |
| CD8+CD38+ | NL | <.001 | NL | .03 |
| CD8+CD57+ (senescent) | 1.00 (0.86–1.17) | .97 | 0.84 (0.71–0.98) | .03 |
| CD8+CD45RO+ (memory) | 0.94 (0.81–1.10) | .46 | 1.21 (0.99–1.47) | .06 |
| CD8+ central memory | 1.03 (0.89–1.19) | .67 | 1.12 (0.95–1.32) | .19 |
| CD8+ transitional memory | 0.97 (0.83–1.12) | .67 | 1.34 (1.09–1.65) | .006 |
| CD8+ effector memory | 0.93 (0.80–1.08) | .33 | 0.96 (0.77–1.20) | .73 |
| CD8+ TEMRA | 0.92 (0.79–1.08) | .33 | 0.91 (0.78–1.08) | .28 |
| CD8+ CD28- | 0.83 (0.71–0.98) | .03 | 0.89 (0.74–1.07) | .22 |
| Soluble Biomarkersb | ||||
| Interleukin-6 | NL | .02 | 1.03 (0.91–1.16) | .66 |
| Soluble CD14 | NL | <.001 | NL | .01 |
| D-dimer | 1.02 (0.89–1.18) | .75 | NL | .006 |
Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus; NL, nonlinear models; TEMRA, T effector memory RA+.
aOdds ratio only provided for linear models.
bModel 3 excluded the soluble biomarker as a covariate that was also the outcome for the model.
NOTE: P < .05 are bolded. Model 3: adjusted for age, sex, body mass index, viral suppression (HIV + only), race, hepatitis C serostatus, smoking status, alcohol use, cytomegalovirus serostatus, interleukin-6, D-dimer, and soluble CD14.