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. 2020 Jul;26(7):1478–1488. doi: 10.3201/eid2607.200841

Figure 1.

Figure 1

Kinetics of antibody responses against SARS-CoV-2 after infection. We tested 1 patient who had severe coronavirus disease 2019 (red) and 2 patients who had mild coronavirus disease 2019 (green and black) for antibody responses against A) S protein, B) S protein S1 subunit, C) S N-terminal (S1A) domain, D) RDB, and E) N protein by using ELISAs. F) Virus-neutralizing antibodies were tested by using a PRNT50. G, H) Reactivities of serum samples from the 3 patients at different time points against whole S (G) and S1 (H) of SARS-CoV-2, SARS-CoV, and MERS-CoV were tested by ELISAs. Dotted horizontal lines indicate ELISA cutoff values. MERS-CoV, Middle East respiratory syndrome coronavirus; N, nucleocapsid; OD, optical density; PRNT50, 50% plaque reduction neutralization test; RBD, receptor-binding domain; S, spike; SARS-CoV, severe acute respiratory syndrome coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.