Table 3. Correlations between ODs/OD ratios and PRNT results of 10 serum samples obtained from 3 PCR-confirmed COVID-19 patients from France and tested in Rotterdam, the Netherlands, 6–27 d after diagnosis*.
| Test, virus | Correlations | In-house ELISAs |
Euroimmun ELISAs |
||||||
|---|---|---|---|---|---|---|---|---|---|
| S1 | N | RBD | S | S1A | IgA | IgG | |||
| PRNT50, SARS-CoV-2 |
Spearman ρ value | 0.87 | 0.94 | 0.92 | 0.94 | 0.93 | 0.98 | 0.92 | |
| 2-tailed p value | 0.0021 | 0.0002 | 0.0005 | 0.0002 | 0.0003 | <0.0001 | 0.0005 | ||
| p value summary |
<0.01 |
<0.001 |
<0.001 |
<0.001 |
<0.001 |
|
<0.0001 |
<0.001 |
|
| PRNT90, SARS-CoV-2 | Spearman ρ value | 0.88 | 0.88 | 0.88 | 0.88 | 0.88 | 0.93 | 0.88 | |
| 2-tailed p value | 0.0024 | 0.0024 | 0.0024 | 0.0024 | 0.0024 | 0.0008 | 0.002 | ||
| p value summary | <0.01 | <0.01 | <0.01 | <0.01 | <0.01 | <0.001 | <0.01 | ||
*COVID-19, coronavirus disease 2019; OD, optical density; N, nucleocapsid; PRNT50, 50% plaque reduction neutralization test; PRNT90, 90% plaque reduction neutralization test; RBD, receptor-binding domain; S, spike; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.