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H&E‐stained specimens through the (A) basilar artery and (B, C) midbrain of a WHHL rabbit (animal 3). The basilar artery demonstrates arterial wall hypertrophy, pronounced neointimal formation (NI) demarcated by black arrows, hypetrophy of the tunica media (TM), and lipid deposition within the atheroma, all consistent with an advanced lesion. (B, C) Rarefaction through the midbrain demonstrates an area of infarct due to the atherosclerotic plaque
