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. Author manuscript; available in PMC: 2021 Jul 27.
Published in final edited form as: Neurosci Lett. 2020 May 1;732:135017. doi: 10.1016/j.neulet.2020.135017

Figure 3. Induced CNS pSer129 αsyn and p62-sequestosome-1 inclusion pathology is similar at motor impairment end stage of IM seeded M83+/− mice regardless of the αsyn C- truncated hPFFs used for seeding.

Figure 3.

Representative immunohistochemical sections from the spinal cord and pons are shown from cohorts IM injected with hPFFs of varied compositions (1-115, 1-119, 1-122, 1-125, 1-129, S129E, and FL human αsyn or 1:1 mixed fibrils with each C-truncated form of αsyn and FL human αsyn). (A) Immunohistochemical staining with pSer129 αsyn antibody 81A. (B) Immunohistochemical staining with anti-p62-sequestosome-1 antibody. Similar densities of neuritic and cellular inclusions are seen for all cohorts in the spinal cord and pons. Scale bar 50 μm.