Table 2. Statistical summary of survival curves for each varied PFF injection experiment.

All mPFF dosage experiments were compared to the 5 μg mPFFs cohort as the control. All comparisons for the PFFs containing C-truncated or phosphomimetic S129E αsyn were made with FL αsyn PFFs as the control. Shown are p-value summaries for survival curve comparisons using the log-rank test or Gehan-Breslow-Wilcoxon (GBW) test.

Comparison	Log rank p value	GBW test p value
Modified hPFFs
1-115 vs FL	****	****
1-119 vs FL	****	****
1-122 vs FL	***	***
1-125 vs FL	**	**
1-129 vs FL	****	****
S129E vs FL (WT)	*	**
Mixed hPFFs
1-115/FL vs FL	NS	NS
1-119/FL vs FL	**	**
1-122/FL vs FL	*	**
1-125/FL vs FL	NS	NS
1-129/FL vs FL	NS	NS
Dosage
10ug vs 5ug	NS	NS
2ug vs 5ug	NS	NS
1ug vs 5ug	NS	NS
0.5ug vs 5ug	NS	NS
0.1ug vs 5ug	**	**
Sex
male vs female	NS	NS

NS = no significance,

^*= p ≤ 0.05,

^**= p ≤ 0.01,

^***= p ≤ 0.001,

^****= p ≤ 0.0001.