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. 2020 Jun 25;13:6073–6083. doi: 10.2147/OTT.S254612

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© 2020 Zhang et al.

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Expression and prognostic value of miR-512-3p in HCC. (A) miR-512-3p levels in 45 human HCC samples and 45 adjacent normal tissue samples (p < 0.0001, Student’s t-test). (B) miR-512-3p levels were higher in the HCC tissues in the current study than the levels derived from normal liver tissues recorded in the TCGA database, accessed via the StarBase V3.0 platform (p = 0.0005, Student’s t-test). (C) qRT-PCR was performed to determine miR-512-3p levels in HCC cell lines (Hep3B, SMMC-7721, MHCC97-L, and HCCLM3) and L02 cells. *p < 0.05, Student’s t-test vs L02, n = 3. (D) In Kaplan–Meier survival analysis HCC patients with higher expression of miR-512-3p (n = 23) exhibited shorter overall survival than those with lower miR-512-3p expression (n = 22). p = 0.0115, Log rank test.