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. 2020 Jun 25;13:6073–6083. doi: 10.2147/OTT.S254612

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© 2020 Zhang et al.

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miR-512-3p mediates the tumor-promoting effects of hypoxia. Western blotting was performed to quantify HIF1-α and LATS2 levels in Hep3B cells cultured under normoxic or hypoxic conditions (A). *p < 0.05, Student’s t-test, n = 3. (B) qRT-PCR was conducted to quantify miR-512-3p levels in Hep3B cells cultured under normoxic or hypoxic conditions. *p < 0.05, Student’s t-test, n = 3. (C) MTT, (D) EdU, and (E) transwell assays were performed to assess the viability, proliferation, migration, and invasion capacities of Hep3B cells with or without miR-512-3p knockdown under hypoxic conditions. *p < 0.05, analysis of variance or Student’s t-test, n = 3.