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. 2020 Jun 25;12:5049–5056. doi: 10.2147/CMAR.S253412

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© 2020 Li et al.

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Overexpression of circ-FOXO3 attenuated cell growth, migration, and invasion of bladder cancer cells by regulating TGFBR2. (A) The different mRNA expression levels of TGFBR2 in bladder cancer tissues and adjacent normal tissues (n=49). (B and C) Cell proliferation levels of both EJ and T24 after the transfection of circ-FOXO3 expression vectors or both circ-FOXO3 expression vectors and TGFBR2 siRNA measured by CCK8 assay. (D and E) Cell migration assay of both EJ and T24 after the transfection of circ-FOXO3 expression vectors or both circ-FOXO3 expression vectors and TGFBR2 siRNA (scale bar: 200 μm). (F and G) Cell invasion assay of both EJ and T24 after the transfection of circ-FOXO3 expression vectors both circ-FOXO3 expression vectors and TGFBR2 siRNA (scale bar: 200 μm). *P<0.05 compared with the control group, **P<0.01 compared with the control group.