Skip to main content
. 2020 Jun 25;181(7):1502–1517.e23. doi: 10.1016/j.cell.2020.05.035

Figure 6.

Figure 6

uvORFs Are Encoded by Cap-Snatching Viruses from Diverse Families

(A) The number of host-virus chimeric protein species potentially encoded by influenza B virus (IBV; B/Wisconsin/01/2010).

(B) Sequence analysis of the PA and NA segments of IBV, showing the translation of the 5′ UTR in all three reading frames and the predicted length distributions of N-terminal extensions to the main ORF and of overprinted new ORFs, calculated from uAUG positions in DEFEND-seq data.

(C) The number of host-virus chimeric protein species potentially encoded by the ambisense genome of Lassa virus (LASV; Josiah strain), in both forward and reverse senses. The ORF encoded by the segment is indicated in the square brackets.

(D) Sequence analysis of L and S segments of LASV in the indicated orientations, showing a schematic of genome organization, the translation of the 5′ UTR in all three reading frames, and the predicted length distributions of overprinted new ORFs, calculated from uAUG positions in CAGE-seq data.