Table 7:
Summary of Antifungal profile of formulations.
|
Candida albicans (WT) (ATCC 90028) |
AmB-resistant Candida albicans (ATCC 200955) |
Aspergillus fumigatus (ATCC 204305) |
|||
|---|---|---|---|---|---|
| Formulations | MIC (μg/mL) (Day 1/ Day10) |
MFC (μg/mL) (Day 1/ Day10) |
MIC (μg/mL) (Day10) |
MFC (μg/mL) (Day10) |
MIC (μg/mL) (Day 1) |
| PEG2K-NLC-AMB | 0.08/0.31 | 0.16/0.31 | 1.25 | 1.25 | 1.25 |
| PEG2K-NLC | NA/NA | NA/NA | NA | NA | NA |
| AmB-NLC | 0.16/0.62 | 0.16/2.5 | NA | NA | 1.25 |
| NLC | NA/NA | NA/NA | NA | NA | NA |
| PA-PEG2K-NLC-AmB | ND/0.16 | ND/0.31 | 1.25 | 2.5 | ND |
| AmB | 0.62/0.62 | 1.25/1.25 | 2.5 | 2.5 | 2.5 |
| Fungizone® | 0.31/0.62 | 0.31/0.63 | 1.25 | 1.25 | 0.62 |
| AmBisome® | 0.62/1.25 | 0.62/1.25 | NA | NA | 1.25 |
*
ND - Not Done, NA - Not Achieved