Table 3.

Summary of the therapeutic effects and administration strategies of exogenous exosomal miRNAs for the treatment of CNS diseases. The cell origins, neuroprotective effects, administration strategies, and specimens of exogenous exosomal miRNAs for the treatment of CNS diseases were listed

Disease	miRNAs	Cell sources	Administration	Affected genes	Effects of miRNA delivery	Specimen	References
Huntington’s disease	miR-124	HEK293	Intracranial	REST	Inhibiting REST expression	Mouse brain	Lee et al. (2017b)
Multiple Sclerosis	miR-219	Immune cells	Intranasal	NeuroD, Pdgfrα, Elovl7	Enhancing OPC differentiation and myelination	Rat hippocampus	Pusic and Kraig (2014)
Glioblastoma	miR-124	MSCs	Intraperitoneal	CDK6, FOXA2	Reducing glioma viability, clonogenicity, migration	Mouse brain	Lang et al. (2017)
	miR-146	MSCs	Intra-tumor	EGFR, NF-kb	Inhibiting glioma growth	Rat brain	Katakowski et al. (2013)
Stroke	miR-133b	MSCs	Intravenous	CTGF, RhoA	Promoting axonal growth and neurite remodeling	Mouse brain	Xin et al. (2013)
	miR-17 ~ 92	MSCs	Intravenous	PTEN	Enhancing neuroplasticity and functional Recovery	Mouse brain	Xin et al. (2017)
	miR-124	MSCs	Intravenous	Gli3, Stat3	Promoting neurogenesis	Mouse brain	Yang et al. (2017)
TBI	miR-124	Microglia	Intravenous	PDE4B	Inhibiting neuroinflammation	Mouse brain	Huang et al. (2018)
	miR-124	MSCs	Intravenous	TLR4 pathway genes	Promoting neurogenesis and function recovery	Rat brain	Yang et al. (2019)