Table 4. Number of days with unscheduled bleeding and/or spotting by treatment period.
| Cycle | DRSP 4mg (N = 858) | DSG 0.075mg (N = 332) | Total (N = 1190) | Wilcoxon-rank-sum-test p value | |
|---|---|---|---|---|---|
| Cycles 2–4 | N | 527 | 222 | 749 | |
| Mean (SD) | 9.6 (11.58) | 16.9 (16.93) | 11.7 (13.80) | <0.0001 | |
| Median | 5.0 | 12.0 | 7.0 | ||
| Min/ Max | 0/66 | 0/79 | 0/79 | ||
| Cycles 5–7 | N | 423 | 157 | 580 | |
| Mean (SD) | 7.4 (9.53) | 10.6 (12.69) | 8.3 (10.56) | 0.0232 | |
| Median | 4.0 | 7.0 | 4.0 | ||
| Min/ Max | 0/67 | 0/61 | 0/67 | ||
| Cycles 7–9 | N | 374 | 137 | 511 | |
| Mean (SD) | 7.2 (8.85) | 10.8 (13.34) | 8.2 (10.35) | 0.0277 | |
| Median | 4.0 | 7.0 | 4.0 | ||
| Min/ Max | 0/51 | 0/83 | 0/83 | ||
| Cycles 2–6 | N | 422 | 172 | 594 | |
| Mean (SD) | 13.7 (15.98) | 23.7 (24.69) | 16.6 (19.44) | <0.0001 | |
| Median | 7.0 | 17.0 | 9.5 | ||
| Min/ Max | 0/89 | 0/134 | 0/134 | ||
| Cycles 2–9 | N | 305 | 116 | 421 | |
| Mean (SD) | 21.5 (22.86) | 34.7 (33.73) | 25.1 (26.92) | 0.0003 | |
| Median | 14.0 | 26.0 | 16.0 | ||
| Min/ Max | 0/95 | 0/156 | 0/156 |
N: number of patients in specified treatment group; n: number of patients with data available; SD: Standard Deviation