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. 2020 Jun 29;15(6):e0235126. doi: 10.1371/journal.pone.0235126

Table 4. Treatment-related complications in patients with surgically resected non-small cell lung cancer with or without idiopathic pulmonary fibrosis.

(A) Surgery-related complications
LC with IPF (n = 96) LC without IPF (n = 192) P-value
Pneumonia 11 (11.5) 25 (13.0) 0.706
Pneumothorax 20 (20.8) 24 (12.0) 0.509
BPF 1 (1.0) 2 (1.0) 1.000
Prolonged MV 2 (2.1) 10 (5.2) 0.224
Arrythmia 1 (1.0) 2 (1.0) 1.000
Bleeding 2 (2.1) 3 (1.6) 0.751
ARDS* 2 (2.1) 2 (1.0) 0.255
AE–IPF 5 (5.2)
ARDS or AE–IPF 7 (7.3) 2 (1.0) 0.012
(B) Adjuvant treatment-related complication (n = 110)
Postoperative hospital day 10.2 ± 10.0 9.8 ± 11.9 0.780
LC with IPF (n = 30) LC without IPF (n = 80) P-value
Cytopenia 2 (6.7) 17 (21.2) 0.091
GI trouble 8 (26.7) 28 (35.0) 0.409
Pneumonia 6 (20.0) 6 (7.5) 0.071
Pneumonitis 1 (3.4) 1 (1.2) 0.469
AE–IPF 2 (6.7) 0 (0.0) 0.126

Values are expressed as number (%).

*ARDS other than AE-IPF

AE-IPF, acute exacerbation of idiopathic pulmonary fibrosis; ARDS, acute respiratory distress syndrome; BPF, bronchopleural fistula; GI, gastrointestinal; LC, lung cancer; MV, mechanical ventilation