Fig. 14.

This diagram of OLs development indicates the stage where our cells (in pink) were when they were submitted to sim-μG. In 1G these cells take around one week to move forward to the next step on the lineage. Here we showed that 3 days in sim-μG cells started and increased the secretion of lipids that weren’t yet myelin lipids but just membrane lipids. We postulate that this increased lipid production was because OLs were moving forwards to next stage in the lineage characterized by the formation of numerous hairy-like cell processes while in microgravity. OLPs kept in 1G did not display this phenomenon.