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. Author manuscript; available in PMC: 2020 Jun 29.
Published in final edited form as: Nature. 2019 Nov 20;575(7784):669–673. doi: 10.1038/s41586-019-1769-z

Extended Data Figure 1. The NLRP3 inflammasome is activated in Tau22 mice.

Extended Data Figure 1.

a, Immunoblot analysis of ASC and β-actin in human cortex of FTD and control patients.

b, Quantification of data from a. Box plots show 25/75 percentile. n=8 for controls, n=9 for FTD, *P=0.0239.

c, Immunohistochemical staining of human cortex of a FTD patient for microglia and ASC. n=3. Scale bar, 20μm.

d, Quantification of % of intracellular ASC and % of extracellular ASC specks from staining shown in Fig 1g. n=6 mice per group, ****P<0.0001.

e, Immunoblot analysis of hippocampus samples of 8 month old wildtype (WT) and Tau22 mice stained for Caspase-1 and β-actin.

f, Quantification of data from e. n=9 per group, *P=0.0489.

g, Immunoblot analysis of hippocampus samples of 8 month old WT and Tau22 mice stained for IL-1β (p17) and β-actin.

h, Quantification of data from g. n=9 per group, *P=0.0236.

For gel source data, see Supplementary Figure 1. All graphs are presented as mean ± SEM and were analyzed by two-tailed unpaired t-test.