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. 2020 Jun 2;130(7):3621–3636. doi: 10.1172/JCI130176

Figure 11. Lack of caspase-11 protects myenteric neurons against palmitate- and LPS-induced pyroptosis.

Figure 11

Primary myenteric neurons were isolated from C57BL/6 (WT) mice and CASP11–/– mice and cultured for 5 to 7 days, and then treated with vehicle, palmitate (PA, 0.5 mM), and/or LPS (0.5 ng/mL) for 24 hours. (A) Representative images of staining for CC1 and Tuj-1. Scale bars: 50 μm. (B) The percentage of CC1+ in Tuj-1+ myenteric neurons is presented. At least 5 fields were selected randomly and data were obtained for each animal. Data presented as the mean ± SEM; n = 3 mice in each group. *P < 0.05; **P < 0.01; ***P < 0.001 by 1-way ANOVA with Dunnett’s multiple-comparisons test and Bartlett’s test of equal variances.