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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: J Immunol. 2020 Mar 20;204(9):2360–2373. doi: 10.4049/jimmunol.2000028

Figure 4. Bone marrow chimeras reveal a functional role for mutant Copa in the thymic stroma.

Figure 4.

A. Representative flow analysis of CD4 and CD8 on reconstituted thymocytes in the bone marrow chimeras after 6–8 weeks of reconstitution.

B. Flow analysis of CD69 and TCRβ expression on the reconstituted thymocytes.

C. Percentages of CD4SP and CD8SP thymocytes among the reconstituted (6–8 weeks of reconstitution) thymocytes (WT→WT, n = 7; WT→HET, n = 6; HET→WT, n = 6; HET→HET, n = 4).

D. Percentages of TCRβ+CD69+ and TCRβ+CD69- population among the reconstituted thymocytes (WT→WT, n = 7; WT→HET, n = 6; HET→WT, n = 6; HET→HET, n = 4).

Data are mean ± SD. Unpaired, parametric, two-tailed Student’s t-test was used for statistical analysis. p < 0.05 is considered statistically significant. ns: not significant.