Table 1.
Studies and findings of important hematological parameters in COVID-19 disease.
| Author (year) | Country | Study period | Sample size | Hematology parameter studied | Study findings |
|---|---|---|---|---|---|
| Huang (2020) | Jinyintan Hospital, Wuhan, China | 16th December 2019-2nd January 2020 | 41 | Lymphopenia (lymphocyte count <1.0 x 109/L) | 85% of patients requiring intensive care demonstrated lymphopenia vs. 54% of patients that did not require intensive care (p = 0.045) |
| Wang (2020) | Zhongnan Hospital, Wuhan, China | 1st January- 3rd February 2020 | 138 | Lymphocyte count as a continuous variable, x109/L | ICU cases presented with lower lymphopenia (median:0.8, IQR: 0.5–0.9) vs. non-ICU cases (median: 0.9, IQR: 0.6–1.2); p = 0.03. Longitudinal decrease was noted in non-survivors. |
| Wu (2020) | Jinyintan Hospital, Wuhan, China | 25th December 2019–13th February 2020 | 201 | Lymphocyte count as a continuous variable, x109/mL in a bivariate Cox regression model | Lower lymphopenia was associated with ARDS, (p < 0.001 in the incremental model); the association with survival did not reach significance, p = 0.11 |
| Fan (2020) | National Centre for Infectious Diseases, Singapore | 23rd January- 28th February 2020 | 69 | Thrombocytopenia; platelet count <100 × 109/L. | Thrombocytopenia was not associated with ICU care either at admission (p = 0.67) or as a nadir during hospital stay (p = 0.69) |
| Yang (2020) | Jinyintan Hospital, Wuhan, China | 24th December 2019-9th February 2020 | 52 | Platelet count treated as a continuous variable ( × 109/L) | Platelet count in non-survivors was 191 (63) and 164 (74) in survivors |
| Wu (2020) | Jinyintan Hospital, Wuhan, China | 25th December 2019–13th February 2020 | 201 | hs-CRP >5 vs. ≤5 mg/L in a bivariate Cox regression model | Higher hs-CRP was associated with ARDS, p = 0.008 |
| Wu (2020) | Jinyintan Hospital, Wuhan, China | 25th December 2019–13th February 2020 | 201 | Serum ferritin >300 vs. ≤300 ng/mL in a bivariate Cox regression model | Hyperferritinemia was associated with ARDS (p = 0.003); the trend of an association with survival did not reach significance (p = 0.10) |
| Wang (2020) | Zhongnan Hospital, Wuhan, China | 1st January- 3rd February 2020 | 138 | Elevated procalcitonin ≥0.05 ng/ml | 75% of ICU patients presented with high procalcitonin vs. 21.6% of non-ICU patients, p < 0.001 |
| Huang (2020) | Jin Yintan Hospital, Wuhan, China | 16th December 2019-2nd January 2020 | 41 | D-dimer as a continuous variable, in mg/L | Patients requiring ICU care demonstrated higher D-dimer levels, p = 0.0042 |