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. 2020 Jun 29;10:10579. doi: 10.1038/s41598-020-67473-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Positive control validation. Validation of 2 active compounds for use as HTS positive controls. (A) Dose–response curves of the compounds in the Fluo2 HTS format. Statistics for the compounds are found below the graph. (B) IP assay for the activity of the GnRHR E90K on the various control compounds in the presence or absence of doxycycline. (C) IP assay for the activity of the WT GnRHR on the various control compounds in the presence or absence of doxycycline.