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. 2020 Jun 29;10:10579. doi: 10.1038/s41598-020-67473-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GnRHR confirmation and counterscreen. (A) The 3-way correlation plot of all compounds tested in all three assay formats represented as average percent response. The red circles represent the 721 selective compounds that are shown in the indicated section of the Venn diagram (I). (B) A Venn diagram representing the active compounds of the three assays. The 721 represents compounds that are active in the GnRHR no DOX Fluo2 assay and GnRHR no DOX IP-One assay and inactive in the GnRHR “+” DOX Fluo2 counterscreen. Each section of active compounds in the Venn diagram are represented by roman numerals, and the matching area of the 3D correlation plot are indicated.