Table 2.
Baseline characteristics of patients with CRPC treated with abiraterone, enzalutamide, docetaxel or watchful waiting
| Treatment | Abiraterone | Enzalutamide | Docetaxel | Watchful waiting |
|---|---|---|---|---|
| n | 249 | 184 | 1006 | 2149 |
| Anti-androgens before CRPC (%) | 114 (46.0) | 81 (44.0) | 397 (39.5) | 788 (36.8) |
| Comorbidity score (%) | ||||
| 0 | 168 (67.5) | 107 (58.2) | 703 (70.0) | 1227 (57.1) |
| 1 | 43 (17.3) | 38 (20.7) | 185 (18.4) | 496 (23.1) |
| 2 | 24 (9.6) | 23 (12.5) | 80 (8.0) | 252 (11.7) |
| 3 | 6 (2.4) | 6 (3.3) | 22 (2.2) | 86 (4.0) |
| 4 | 5 (2.0) | 4 (2.2) | 8 (0.8) | 46 (2.1) |
| 5 | 0 (0.0) | 2 (1.1) | 3 (0.3) | 13 (0.6) |
| 6 | 3 (1.2) | 2 (1.1) | 4 (0.4) | 17 (0.8) |
| 7 | 0 (0.0) | 1 (0.5) | 0 (0.0) | 5 (0.2) |
| 8 | 0 (0.0) | 1 (0.5) | 0 (0.0) | 5 (0.2) |
| Bone metastases (%) | 142 (87.7) | 103 (87.3) | 703 (91.1) | 929 (81.7) |
| Lymph node metastases (%) | 66 (80.5) | 41 (83.7) | 373 (82.5) | 507 (76.6) |
| Visceral metastases (%) | 8 (16.7) | 8 (24.2) | 57 (21.7) | 52 (16.1) |
| WHO (%) | ||||
| 1 | 37 (40.2) | 26 (43.3) | 222 (42.0) | 360 (47.1) |
| 2 | 41 (44.6) | 21 (35.0) | 245 (46.3) | 317 (41.5) |
| 3 | 14 (15.2) | 13 (21.7) | 62 (11.7) | 87 (11.4) |
| Pain (%) | 47 (42.0) | 28 (37.8) | 317 (49.2) | 323 (31.0) |
| Opioid use (%) | 22 (32.8) | 9 (24.3) | 120 (29.3) | 113 (22.7) |
| Gleason > 7 (%) | 143 (67.8) | 105 (65.2) | 591 (65.9) | 998 (55.5) |
| Time to castration (median [range]) | 11.17 [1.4, 192] | 13.34 [1, 196] | 10.12 [0.2, 172.7] | 20.47 [0.3, 248.4] |
| Age (median [range]) | 76.00 [46, 95] | 77.00 [50, 94] | 70.00 [46, 93] | 78.00 [49, 99] |
| Weight (median [range]) | 83.00 [52, 120] | 86.00 [60, 120] | 84.50 [48, 150] | 81.00 [44, 118] |
| Hemoglobulin (median [range]) | 8.00 [5.1, 9.6] | 8.00 [4.7, 10.3] | 8.00 [4.3, 10.2] | 8.10 [3.9, 10.5] |
| Platelets (median [range]) | 234.00 [37, 569] | 228.50 [54, 473] | 243.00 [0.4, 749] | 233.00 [0.3, 714] |
| Lactate dehydrogenase (median [range]) | 218.00 [72, 3179] | 216.00 [98, 730] | 232.00 [21, 4100] | 218.00 [79, 4329] |
| Alkaline phosphatase(median [range]) | 122.00 [41, 1673] | 109.00 [38, 1263] | 136.00 [34.8, 3457] | 93.00 [21, 4315] |
| PSA (median [range]) | 34.00 [0.1, 8730] | 24.40 [0.1, 4150] | 40.00 [0.0, 8700] | 9.70 [0.1, 4034] |