Table 3.
Genomic features as a reference panel
| Type | Age | Sex | Populationa | Fusion gene | Hotspot mutation | TP53 | FLT3 | Chromosome rearrangements | Array | p16 | Candidate causative genes | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kasumi-3 | AML-M0 | 57 | M | JP | ETV6(12p13.2) | t(3;7)(q27;q22) | 7p-, 12p13 LOH | |||||
| Kasumi-1 | AML-M2 | 7 | M | KR-HAN | RUNX1-RUNX1T1 | KIT | p.Arg248Gln | -Y, t(8;21)(q21;q22) | + 10, 17p- | LOH | ||
| Kasumi-6 | AML-M2 | 64 | M | KR-JP | WT1, STAG2,CEBPAb | p.Tyr234Asp | ITD | add(12)(p11), add(13)(p11) | + 10, 13q + , 17p- | |||
| Kasumi-4 | CML-BC | 6 | F | JP | BCR-ABL1 | GATA2 | t(9;22;11)(q34;q11;q13) | Normal | ||||
| Kasumi-5 | T-ALL | 24 | M | HAN-TW | NUP98-RAP1GDS1b | t(4;11)(q21;p15) | 3pUPD,12p-, 17p- | KIT, NOTCH1, SETBP1, CREBBP | ||||
| Kasumi-2 | BCP-ALL | 15 | M | JP | TCF3-PBX1 | HRAS | t(1;19)(q23;p13) | 1q + , 6q-,7p-, 7q + | TAL1, TET2, KRAS, NF1, ATRX | |||
| Kasumi-7 | BCP-ALL | 29 | F | JP | t(4;9)(q21;?), del(9p) | del (TMEM2) | del | ABL1 | ||||
| Kasumi-8 | BCP-ALL | 48 | M | JP | BCR-ABL1 | ETV6 (12p13.2) | t(9;22)(q34;q11) | 12p13.2 LOH | del | APC | ||
| Kasumi-9 | BCP-ALL | 19 | M | JP | DNAH11 LOH | del | GLI2. MECOM, JAK2 | |||||
| Kasumi-10 | BCP-ALL | 6 M | F | KR-JP | KMT2A-MLLT1 | ITD | t(11;19)(q23;p13.3) | XXY | GATA3, FLT3 |
aPopulations JP: Japanese, KR: Korean, HAN: Han Chinese, TW: Taiwanese
bFusion gene and mutation were not detected in this study but were reported by previous studies