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. 2020 May 23;146(8):1941–1951. doi: 10.1007/s00432-020-03246-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — In vivo identification of miR-155-5p and fluorescence imaging of cancer cells in transgenic mice at different stages of the disease. a Imaging the lung after injection of CS-miR-155-5p MB nanoparticles via the tail vein. Mice without intranasal inhalation of the adenovirus were used as the control group. b Imaging the lungs after removal. c Fluorescence intensity was analyzed after injection (n = 8) (*p < 0.05). d Confocal microscopy imaging of the different pathological changes after transfection with CS-miR-155-5p MB. Cell nuclei were stained by DAPI (blue). Scale bar 50 μm. Arrow ①: atypical hyperplasia. Arrow ②: adenoma. Arrow③: carcinoma in situ. Arrow ④: adenocarcinoma