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. 2020 Jun 19;146(8):2077–2087. doi: 10.1007/s00432-020-03290-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Forest plot of overall treatment effect of chemotherapeutic escalation regarding overall survival for patients with RAS wildtype (WT) and mutated (MUT) tumors b Forest plot of overall treatment effect of escalation by anti angiogenic escalation regarding overall survival for patients with RAS wildtype (WT) and (MUT) tumors. OS overall survival, HR hazard ratio, 95% CI 95% confidence interval, RE random effects model. FOCUS upfront IrFU/OxFU vs. FU. FOCUS 5-FU: sequential 5-FU then IrFU/OxFU vs. FU