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. 2020 May 8;295(26):8808–8818. doi: 10.1074/jbc.RA119.010129

Figure 6.

Figure 6.

Expression of c-Fos is involved in cortical development. A, embryo brains were electroporated with a specifically designed shRNA to block c-Fos expression (sh c-Fos) (right) or a control scrambled shRNA (left) at E15 and analyzed at E19. IUE, in utero electroporation; MZ, marginal zone. Scale bar, 100 μm. B, quantification of the distribution of dsRed-positive cells in the CP, IZ, and VZ/SVZ. The mean ± S.D. of the quantification of at least 20 coronal cryosections from three independent experiments performed independently is shown, with two-way ANOVA with Bonferroni post-test. ***, p < 0.001; n.s., nonsignificant. C, embryo brains were electroporated with a vector designed to express the NA domain of c-Fos fused to CFP or the empty vector as a control at E15 and analyzed at E19. D, quantification of the distribution of dsRed-positive cells in the CP, IZ, and VZ/SVZ. The mean ± S.D. of the quantification of at least 20 coronal cryosections from three independent experiments performed independently is shown, with two-way ANOVA with Bonferroni post-test. ***, p < 0.001; **, p< 0.001.