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. 2020 Jun 23;11:583. doi: 10.3389/fphys.2020.00583

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Copyright © 2020 Abbott.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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KCNQ residues influential in effects of PIP₂, GABA, and metabolites. (A) KCNQ1–KCNQ3 chimeric structural model showing residues important for effects of PIP₂ (yellow) and GABA and metabolites (red). PH, pore helix. (B) Close-up of residues in A with human KCNQ3 residue numbering.