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. 2020 Jun 23;11:583. doi: 10.3389/fphys.2020.00583

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Copyright © 2020 Abbott.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Molecular basis for cilantro anticonvulsant effects. (A) Images of cilantro (left) and culantro (right). Required photo permissions: https://creativecommons.org/licenses/by/2.0/; https://commons.wikimedia.org/wiki/File:Culantro_(Eryngium_foetidum)_6.jpg. (B) Left, structures and Jmol surface electrostatic potential plots of three structurally similar fatty aldehydes; right, their corresponding effects on KCNQ2/3 G/V relationships (quantified from tail currents). Adapted from Manville and Abbott (2019a) with permission. (C) SwissDock prediction of E-2-dodecenal binding poses in KCNQ2. Blue, VSD; sand, S5; pink, S4, S5 linker.