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. 2020 Jun 29;10:10559. doi: 10.1038/s41598-020-67499-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NTCP modeling of radiation-induced effects to the lung: dose response data and model-fits for stereotactic body radiation therapy-induced injury of the lungs. Blue dots (P(D)) represent the radiation-induced effects, defined as the cumulative change in CT HU over all associated patients, normalized from 0 to 1 based on the maximal CT HU change seen at the particular time point. Blue, orange, gray, and yellow lines represent the Logit, Lyman, Weibull, and Poisson dose response models, respectively, fit to the data points. (a) The data and fits of six patients at 2–5 months after radiation therapy. These time points reflect radiation pneumonitis. (b) The data and fits of six patients at 6–9 months after radiation therapy. These time points reflect radiation-induced lung fibrosis. (c) The data and fits of all 12 patient data sets over all time points.