Table 2.

Relationship of right frontal lobe metabolite concentrations with infant’s age (postmenstrual, gestational and postnatal), and sex.

Metabolite	Association between metabolites and infant’s age and sex (β, p-value)
	Postmenstrual age 1H–MRS	Gestational Age at birth	Postnatal age at 1H–MRS	Male sex	PMA at 1H–MRSa
GABA +	0.05, 0.11	−0.08, 0.01	0.06, 0.02	0.33, 0.02	0.03, 0.43
Glutamate DIFF	0.14, 0.02	−0.15, 0.06	0.13, 0.005	0.37, 0.21	0.12, 0.07
Glutamate OFF	0.16, 0.007	−0.06, 0.55	0.11, 0.02	0.27, 0.50	0.22, 0.02
Glx DIFF	0.25, 0.01	−0.20, 0.04	0.20, 0.008	1.46, 0.005	0.17, 0.02
Glx OFF	0.17, 0.03	−0.08, 0.37	0.12, 0.04	0.48, 0.20	0.17, 0.08
NAA	0.32, 0.002	−0.10, 0.20	0.21, 0.003	0.49, 0.19	0.31, 0.006
Choline	0.03, 0.08	−0.05, 0.03	0.03, 0.03	0.18, 0.05	0.02, 0.36
Cr	0.18, 0.003	−0.08, 0.20	0.13, 0.008	0.39, 0.07	0.14, 0.01
Ins	0.09, 0.29	−0.10, 0.32	0.08, 0.22	0.34, 0.42	0.06, 0.38
GABA +/Cho	0.01, 0.27	−0.02, 0.05	0.02, 0.09	0.11, 0.11	0.01, 0.57
GABA +/Cr	−0.01, 0.28	−0.02, 0.04	0.00, 0.79	0.05, 0.21	−0.01, 0.27

Estimates from generalized estimating equations.

^aAdjusted for GA at birth, sex, race, and 5 minute Apgar.