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. 2020 Jun 29;10:10544. doi: 10.1038/s41598-020-67197-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The figure shows the absolute change of BODE-Index as derived from multiple linear regression analysis adjusting for sex, age, BMI and pack years for defined changes in four selected predictors. The change is given for a change in OxyHem by −2 g/dL, in WBC count by +2000/µL, or the presence of coronary artery disease (CAD) or heart failure (HF). Additionally, the numerical values of the changes in the BODE-Index, their 95% confidence intervals and the corresponding p values are shown.