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. 2020 Jun 29;10:10515. doi: 10.1038/s41598-020-65580-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The protective effects of preventative G-CSF treatment on BLM-induced pulmonary fibrosis. (A) Experimental design 1: Preventative treatment with G-CSF (40 µg/kg) was performed daily from day 1 to day 3. Mice were sacrificed, and lung tissues were harvested on day 21 for further testing. (B) The pathological examination of the lung sections utilized H&E staining (upper row) and Masson’s trichrome staining (lower row) (scale bar =100 µm, ×100). (C) The Ashcroft scoring method was used to determine the severity of pulmonary fibrosis. (D) The collagen content was quantified by HYP assay. (E) The mRNA expression levels of collagen I and III were also determined by real-time PCR. n = 4–6. *P < 0.05, **P < 0.01 between the indicated groups. Bars: mean ± SD.