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. 2020 Jun 23;11:1182. doi: 10.3389/fimmu.2020.01182

Figure 2.

Figure 2

Main tolerogenic mechanisms of the FoxP3−HLA-G+ regulatory T cell. HLA-G+ regulatory T cells can suppress in a cell-contact dependent manner via HLA-G1. It inhibits the killing capacity of T cells and NK cells, downregulates HLA class II, CD80, and CD86 in DCs and macrophages, and makes them tolerogenic by inducing IDO production in macrophages and the induction of DCs to DC-10 cells. HLA-G+ regulatory T cells produce IL-10 and soluble HLA-G5 that helps to create a tolerogenic decidual microenvironment. HLA, human leukocyte antigen; NK, natural killer cell; DC, dendritic cell; IDO, indoleamine 2,3-dioxygenase; IL-10, interleukin-10; DC-10, tolerogenic DCs.