TABLE 3.
OTUs with differential abundance in breast milk samples from mothers whose children later developed celiac disease (CeD) compared to those whose children remained healthy (controls) according to LMM analysis.
| OTU | Association1 | Variation2 | p-Value | Blast (% alignment, % identity)3 SINA classsification4 |
| OTU179 | CeD | −1.03 | 0.0010 | (g) Muribaculum sp. (100, 95) |
| (f) Muribaculaceae (92.8) | ||||
| OTU62 | CeD | −1.09 | 0.0195 | (s) Peptoniphilus timonensis (100, 99) |
| (g) Peptoniphilus (99.4) | ||||
| OTU42 | CeD | −1.12 | 0.0193 | (s) Methylobacterium komagatae (100, 99) |
| (g) Methylobacterium (99.4) | ||||
| OTU54 | CeD | −1.04 | 0.0233 | (s) Methylocapsa palsarum (100, 98) |
| (f) Beijerinckiaceae (97.9) | ||||
| OTU13 | CeD | −1.19 | 0.0320 | (s) Bacteroides vulgatus (100, 99) |
| (g) Bacteroides (99.7) | ||||
| OTU143 | CeD | −0.77 | 0.0257 | (s) Atopostipes suicloacalis (100, 97) |
| (f) Carnobacteriaceae (100) | ||||
| OTU483 | CeD | −0.60 | 0.0343 | (s) Actinomyces turicensis (100, 99) |
| (g) Actinomyces (99.7) | ||||
| OTU73 | CeD | −0.85 | 0.0317 | (s) Wautersiella falsenii (100, 99) |
| (g) Empedobacter (98.5) |
1Association with celiac disease (CeD) development; the breast milk samples showed increased abundance in the taxonomic group recorded. 2Variation calculated taking into account the control samples as reference and based on normalized DNA read counts by logarithmic transformation. 3Taxonomic identification based on best hit during the alignment using the non-redundant 16S rRNA gene NCBI database. 4Taxonomic identification based on SINA aligner using the SILVA reference database and sequence identity value against the last common ancestor (lca). S, species; g, genus; f, family.