Table 2.

Disproportionality analysis of cognitive impairment or dementia associated with the use of benzodiazepines in all adverse events and applied to reports with certain, probable, and possible causality assessments from KIDS-KD, 2007–2016

		Before matching						After matching on age and sex (1:10)
		ROR	95% CI		Adjusted ROR*	95% CI		ROR	95% CI		Adjusted ROR*	95% CI
			Lower limit	Upper limit		Lower limit	Upper limit		Lower limit	Upper limit		Lower limit	Upper limit
Including all causality assessments
	Benzodiazepine	1.98	1.51	2.59	2.04	1.55	2.68	2.00	1.49	2.69	2.23	1.61	3.09
Restricted to adverse events with causality recorded as certain, probable, and/or possible
	Benzodiazepine	2.85	1.87	4.35	2.70	1.76	4.12	2.58	1.62	4.12	2.69	1.66	4.38

^*adjusted according to age group, sex, year of reporting, polypharmacy, and comorbidity.

KIDS-KD: Korea Institute of Drug Safety & Risk Management-Korea adverse event reporting system database, ROR: reporting odds ratio, 95% CI: 95% confidence interval