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. 2020 Jun 23;11:714. doi: 10.3389/fphys.2020.00714

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Copyright © 2020 Yap, McCurdy, Alcala, Irei, Garo, Regan, Lee, Kitamoto and Boisvert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A,B) Measurements of serum cholesterol and triglyceride were taken after 12 weeks of HFD. Colorimetric and fluorometric analysis revealed no significant difference between control mice and CHIT1-OE mice. (C) Animals were weighed before and after initiation of HFD, which showed significant weight gain within groups over the 12 week period. However, animal weights were not significantly different when compared between CHIT1-OE and control groups (P < 0.0001). N = 24 (12 per group), ****P < 0.0001.