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Definition of liver injury.
| Indicators | Liver injurya | Mild liver injuryb | Moderate liver injuryc | Severe liver injuryd |
|---|---|---|---|---|
| ALT | >1 ULN | >1–3 ULN | >3–5 ULN | >5 ULN |
| AST | >1 ULN | >1–3 ULN | >3–5 ULN | >5 ULN |
| ALP | >1 ULN | >1–2.5 ULN | >2.5–5 ULN | >5 ULN |
| TBIL | >1 ULN | >1–1.5 ULN | >1.5–3 ULN | >3 ULN |
Liver injury, mild, moderate, and severe liver injury were defined as the occurrence of any of the listed abnormal liver function indicators in the corresponding columns, respectively.
