FIGURE 1.

Mechanical properties of aorta segments from male and female diabetic db/db and normoglycaemic db/db+ mice. Aorta segments from diabetic db/db mice show (A) reduced wall thickness (WT) in segments from male db/db (n = 10) versus db/db+ (n = 8) mice, but not in female db/db (n = 12) and db/db+ (n = 14) mice and (B) reduced maximal load (Fmax), (C) unaltered maximal elastic modulus, and (D) reduced viscoelasticity. The results are means ± SEM. *P < 0.05, db/db versus db/db+ controls. ^#P < 0.05, female versus male mice in same condition.