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. 2020 Jun 23;11:667. doi: 10.3389/fphys.2020.00667

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Copyright © 2020 Beck, Su, Comerma-Steffensen, Pinilla, Carlsson, Hernanz, Sheykhzade, Danielsen and Simonsen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Structural and mechanical changes in left anterior descending (LAD) coronary artery from male diabetic mice. (A,B) Increasing pressure (10–140 mmHg) changes in external (De) and internal (Di) diameters, (C,D) wall thickness, (E,F) wall:lumen ratio, and (G,H) incremental distensibility. The vessel wall thickness is significantly lower in male mice, while distensibility is significantly higher in arteries from male db/db mice and significantly lower in arteries from female db/db mice compared to the db/db+ controls. The results are means ± SEM. *P < 0.05, db/db (n = 6) versus db/db+ controls (n = 6).