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. 2020 Jun 23;11:667. doi: 10.3389/fphys.2020.00667

FIGURE 5.

FIGURE 5

Impaired endothelium-dependent relaxation in aorta from diabetic db/db mice. Average aorta relaxations in segments contracted with phenylephrine. (A) Impaired acetylcholine (ACh) relaxation in diabetic db/db male mice (n = 6) compared to normoglycaemic db/db+ male mice (n = 6). (B) Impaired acetylcholine relaxation in diabetic db/db female mice (n = 6) compared to normoglycaemic db/db+ (n = 7) female mice. (C) The impairment of acetylcholine relaxation was more pronounced in aorta segments from female compared to male diabetic db/db mice. (D) Impaired SNP relaxation in aorta from diabetic db/db male mice (n = 6) compared to normoglycaemic db/db+ (n = 7) male mice. (E) Unaltered relaxations induced by the NO donor sodium nitroprusside (SNP) in diabetic db/db female mice (n = 6) compared to normoglycaemic db/db+ female mice (n = 6). (F) SNP relaxations were similar in aorta segments from male and female db/db mice. The results are means ± SEM. *P < 0.05 db/db versus db/db+ control mice. #P < 0.05, female versus male mice in the same condition.